2010 South Buffalo Football season schedule.
Game Times:
Saints 10:00 am
Leps Noon
Tigers 2:00 pm
Shamrocks 4:00 pm
| DATE | GAMES |
| August 28th: | EMW @ South Buffalo |
| September 4th: | Lake Shore @ South Buffalo |
| September 11th: | Bye week, Shamrocks @ W.S. East |
| September 18th: | W.S. West @ South Buffalo (Varsity EMW at S.Buffalo) |
| September 25th: | South Buffalo @ KAT |
| October 2nd: | South Buffalo @ West Seneca East |
| October 9th: | NCAAA @ South Buffalo |
| October 16th: | South Buffalo @ EMW (Games Noon, 2, 4 & 6 P.M. |
| October 23rd: | South Buffalo @ Lake Shore |
| October 30th: | Playoffs |
| November 6th: | Playoffs |
| November 13th: | Championships |